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Registry Watchtower

Know what changed—not merely what exists.

Follow model-family releases and the source registry behind them. GitHub metadata can be checked automatically; scientific claims, licenses and product changes remain reviewable evidence rather than silent automated edits.

22curated release events
158configured sources
48GitHub sources automatable
0locally watched model families
Change feed

Curated model evolution

22 events
version release

OpenFold3 Preview entered the model lineage

OpenFold · OpenFold Consortium / Columbia

Extended the OpenFold lineage from AF2 reproduction toward a trainable AF3-class biomolecular model.

version release

Stack entered the model lineage

State / Stack · Arc Institute

Extended the State lineage toward broader in-context generalization rather than treating State and Stack as one static model.

version release

Boltz-2 entered the model lineage

Boltz-1 / Boltz-2 · MIT (Barzilay & Jaakkola labs)

Added a learned affinity capability to the open Boltz structure lineage.

version release

BoltzGen entered the model lineage

BoltzGen · MIT / Boltz team

Extended Boltz from structure/affinity prediction into generative design.

version release

Chai-2 entered the model lineage

Chai-1 / Chai-2 · Chai Discovery

Expanded the Chai lineage from multimodal complex prediction into generative therapeutic design.

version release

Evo 2 entered the model lineage

Evo / Evo 2 · Arc Institute + Stanford + NVIDIA

Scaled the Evo lineage toward genome-scale reasoning and design.

version release

RFantibody entered the model lineage

RFantibody · Institute for Protein Design, UW

Extended RFdiffusion-style generative structural modelling into antibody design.

version release

RFdiffusion2 entered the model lineage

RFdiffusion · Institute for Protein Design, UW

Moved the RFdiffusion lineage from backbone-first generation toward atom-level functional design.

version release

State entered the model lineage

State / Stack · Arc Institute

Established Arc's virtual-cell perturbation prediction lineage.

version release

AlphaFold 3 entered the model lineage

AlphaFold 2 / 3 · Google DeepMind

Replaced the AF2 structure module with a diffusion-based architecture and broadened supported complex types.

version release

Boltz-1 entered the model lineage

Boltz-1 / Boltz-2 · MIT (Barzilay & Jaakkola labs)

Released code and weights under commercially usable terms.

version release

Chai-1 entered the model lineage

Chai-1 / Chai-2 · Chai Discovery

Established Chai Discovery's first openly accessible complex-prediction model.

version release

ESM3 entered the model lineage

ESM3 · EvolutionaryScale (now CZ Biohub)

Unified sequence, structure and functional annotations in one generative model family.

version release

Evo entered the model lineage

Evo / Evo 2 · Arc Institute + Stanford + NVIDIA

Introduced a large genomic foundation model trained at nucleotide resolution.

version release

RoseTTAFold All-Atom entered the model lineage

RoseTTAFold / All-Atom · Institute for Protein Design, UW

Extended the RoseTTAFold family beyond protein-only representations.

version release

LigandMPNN entered the model lineage

ProteinMPNN / LigandMPNN · Institute for Protein Design, UW

Extended the ProteinMPNN concept to functional sites and molecular partners.

version release

RFdiffusion entered the model lineage

RFdiffusion · Institute for Protein Design, UW

Converted a structure-prediction lineage into a generative protein-design system.

version release

OpenFold (AF2 reproduction) entered the model lineage

OpenFold · OpenFold Consortium / Columbia

Made AlphaFold-style training and research reproducible in an open PyTorch implementation.

version release

ProteinMPNN entered the model lineage

ProteinMPNN / LigandMPNN · Institute for Protein Design, UW

Made sequence design a practical downstream step after backbone generation.

version release

AlphaFold-Multimer entered the model lineage

AlphaFold 2 / 3 · Google DeepMind

Extended the AlphaFold 2 family from monomers to protein assemblies.

version release

RoseTTAFold entered the model lineage

RoseTTAFold / All-Atom · Institute for Protein Design, UW

Introduced joint reasoning across one-, two- and three-dimensional representations.

version release

AlphaFold 2 entered the model lineage

AlphaFold 2 / 3 · Google DeepMind

Established the modern deep-learning structure-prediction baseline.