What it is
RoseTTAFold introduced a 'three-track' architecture reasoning jointly over sequence, distances and coordinates. RoseTTAFold All-Atom (2024) models proteins together with small molecules, nucleic acids and covalent modifications. David Baker's lab is the epicenter of open protein AI and shared the 2024 Nobel Prize in Chemistry.
Evidence trail
BioAtlas keeps the path from source to decision visible. A connection records provenance; it does not imply that evidence is sufficient for every context.
Model passport
How RoseTTAFold / All-Atom represents biology
Category is navigation. These fields describe the model-specific computational transformation and deliberately override broad category defaults.
Biological scale
Modalities & tasks
Registry, claims and frontier intelligence
RoseTTAFold All-Atom
2 version records · latest curated year 2024. Model-family identity remains separate from capability and access changes.
Explore version lineage →1 normalized claim
Protein structure prediction · CASP14 / complex modelling
Open claim intelligence →0 connected frontiers
No frontier-research record currently connects to this model.
Inspect research horizon →Inputs and outputs
Inputs
Biomolecular sequence or structure contextOutputs
3D structuresConfidence estimatesScientific and technical profile
Scientific principles
Technology
Scientific lineage
These are transparent concept matches—not claims that one scientist alone caused this model. Each connection is based on the model’s recorded domain, scientific principles, technical terms or an explicit lineage link.
Anfinsen’s dogma—the thermodynamic hypothesis
Christian B. AnfinsenProtein structure prediction, inverse folding and generative protein design all assume that sequence strongly constrains structure and function.
Computational protein structure prediction and de novo design
David BakerModern binder design, inverse folding and diffusion-based protein generation build on this computational-design lineage.
Atomic structures of biologically important molecules by X-ray crystallography
Dorothy Crowfoot HodgkinStructure-based drug design depends on the experimental structural tradition she helped establish.
X-ray evidence for the helical structure of DNA
Rosalind Franklin & Raymond GoslingStructural genomics and sequence-to-structure reasoning began with experimentally grounded molecular geometry.
First atomic structures of globular proteins
John Kendrew & Max PerutzProtein structure prediction and structure-based design became meaningful because experimental crystallography established the target reality to predict against.
Information, entropy and communication
Claude E. ShannonSequence modelling, cross-entropy training, language models, mutual information and representation learning all use Shannon’s framework.
Evaluation evidence
Task-specific evidence only; not comparable as a universal leaderboard score.
CASP14 / complex modelling
RoseTTAFold All-Atom · CASP14 and held-out structure targetsCompetitive three-track structure prediction reported in the primary publication.
Claim caveats
- Results across RoseTTAFold generations are not interchangeable.
- All-atom complex evaluation requires a task-specific benchmark.
Known limitations
- Performance depends on the evaluation dataset and operating conditions.
- Task-specific benchmark results should not be compared across unlike domains.
- Outputs require task-specific scientific and experimental validation.
Milestones
David Baker won the 2024 Nobel Prize in Chemistry.
Foundation for RFdiffusion & ProteinMPNN.