Evo 2 entered the model lineage

Why this model matters

Evo is a DNA foundation model that operates from nucleotides to whole genomes, predicting and designing across DNA, RNA and protein. Evo 2 (2025, with NVIDIA) scaled to 9.3 trillion base pairs across 128,000+ genomes spanning all domains of life — one of the largest biological models built. Evo designed a working CRISPR system (EvoCas9-1) that succeeded after just 11 tries.

Current evidence boundary

• Performance depends on the evaluation dataset and operating conditions.
• Task-specific benchmark results should not be compared across unlike domains.
• Outputs require task-specific scientific and experimental validation.