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Model update · 2025 · developer

Chai-2 entered the model lineage

Expanded the Chai lineage from multimodal complex prediction into generative therapeutic design.

ModelChai-1 / Chai-2
OrganizationChai Discovery
Year2025
Event typeversion-release
Evidence sourcedeveloper
Editorial statuscurated

Why this model matters

Chai-1 is a multi-modal biomolecular structure model on par with AlphaFold 3 for predicting proteins with ligands, nucleic acids and multimers. Chai Discovery (backed by OpenAI and Thrive) released it free for research and drug discovery, and followed with Chai-2 for zero-shot antibody design.

Current evidence boundary

  • Performance depends on the evaluation dataset and operating conditions.
  • Task-specific benchmark results should not be compared across unlike domains.
  • Outputs require task-specific scientific and experimental validation.