Boltz-1 entered the model lineage

Why this model matters

Boltz-1 was the first fully open, commercially-usable model to match AlphaFold 3 on biomolecular complex prediction. Boltz-2 (2025) added fast, accurate binding-affinity prediction — approaching physics-based free-energy methods at a fraction of the cost — a key missing piece for virtual screening.

Current evidence boundary

• Performance depends on the evaluation dataset and operating conditions.
• Task-specific benchmark results should not be compared across unlike domains.
• Outputs require task-specific scientific and experimental validation.